BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.1//EN TZID:Europe/Paris X-WR-TIMEZONE:Europe/Paris BEGIN:VEVENT UID:111@iem.umontpellier.fr DTSTART;TZID=Europe/Paris:20240701T143000 DTEND;TZID=Europe/Paris:20240701T143000 DTSTAMP:20240610T150611Z URL:https://iem.umontpellier.fr/events/conference-de-prof-r-wickramasinghe -1-7-2024/ SUMMARY:Conférence de Prof. R. WICKRAMASINGHE - 1/7/2024 DESCRIPTION:Prof. Ranil Wickramasinghe\nDistinguished Professor et Directeu r du Membrane Science\, Engineering and Technology Center\nUniversity of A rkansas\,\nlundi 1er juillet 2024 à 14h30\, salle de conférences IEM\n\n Development of Membrane Based Bioseparations\nfor Emerging Purification Ch allenges\n \;\n\nBiopharmaceutical manufacturing processes make use of cell lines to produce therapeutics such as monoclonal antibodies\, fusion proteins etc. The manufacturing process is divided into upstream cell cul ture and downstream purification operations. Today\, due to improvements i n cell titers there is increased demand for the development of efficient d ownstream purification operations. Membrane based unit operations are attr active as they are easy to scale up and often involve gentle processing co nditions. Nevertheless\, low product recovery as well as membrane fouling remain a concern.\n\nThis presentation is divided into two parts. In the f irst part common membrane based unit operations will be identified. In par ticular the benefits of membrane adsorbers over packed bed chromatography will be highlighted. The advantages of using salt responsive ligands for m embrane based hydrophobic interaction chromatography will be discussed.\n\ nIn the second part of this presentation future trends in biopharmaceutica l manufacturing processes will be discussed. Today\, biopharmaceutical man ufacturing processes are typically run in batch mode. Further there is gro wing interest in complex therapeutics\, e.g.\, live attenuated virus vacci nes\, viral vectors for delivery of gene therapy\, VLPs\, plasmid DNA\, ce ll-based therapies. These more complex therapeutics create additional chal lenges for the downstream purification operations. Some of these challenge s will be discussed. In addition\, there is a great deal of interest in de veloping continuous biomanufacturing processes in order to minimize batch to batch variation. Continuous biomanufacturing processes will result in m ore efficient equipment usage as well as greater flexibility. While advanc es have been made in continuous upstream cell culture operations (e.g.\, p erfusion operations) many downstream purification operations remain batch processes.\n\nMembrane based bioseparations are run in batch mode. Develop ment of continuous membrane based bioseparations is essential. The present ation will highlight virus filtration. Virus filtration is routinely used for validation of virus clearance in the manufacture of biopharmaceutical products. Validation of virus clearance is required by regulatory agencies . However\, development of virus filtration operations that are compatible with continuous biomanufacturing operations will be essential. Our result s indicate that development of membranes that are compatible with constant flux operation as opposed current practice which is based on constant pre ssure operation will be required\n\n \;\nBio: Ranil Wickramasinghe is a distinguished professor in the Department of Chemical Engineering at th e University of Arkansas where he holds the Ross E Martin Chair in Emergin g Technologies. He is an Arkansas Research Alliance Scholar. He is the Dir ector of the Membrane Science\, Engineering and Technology (MAST) Center\, a National Science Foundation Industry-University Cooperative Research Ce nter. Prof Wickramasinghe is the Executive Editor of Separation Science an d Technology. Prof Wickramasinghe obtained his bachelor’s and master’ s degrees from the University of Melbourne in Chemical Engineering. He obt ained his PhD from the University of Minnesota\, also in Chemical Engineer ing. Prof Wickramasinghe’s research interests are in membrane science an d technology. His research focuses on synthetic membrane-based separation processes for purification of pharmaceuticals and biopharmaceuticals\, tre atment and reuse of water and for the production of biofuels. Typical unit operations include: microfiltration\, ultrafiltration\, virus filtration\ , nanofiltration\, membrane extraction\, membrane distillation etc. A curr ent research focus is surface modification of membranes in order to impart unique surface properties. His group is actively developing responsive me mbranes. These membranes change their physical properties in response to c hanged environmental conditions. A second research focus is the developmen t of catalytic membranes for biomass hydrolysis by grafting catalytic grou ps to the membrane surface.\n \; CATEGORIES:Conférence END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Paris X-LIC-LOCATION:Europe/Paris BEGIN:DAYLIGHT DTSTART:20240331T030000 TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR