BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.1//EN TZID:Europe/Paris X-WR-TIMEZONE:Europe/Paris BEGIN:VEVENT UID:18@iem.umontpellier.fr DTSTART;TZID=Europe/Paris:20221208T000000 DTEND;TZID=Europe/Paris:20221208T000000 DTSTAMP:20230717T150246Z URL:https://iem.umontpellier.fr/events/phd-defense-of-sanaa-daakour-8-12-2 022/ SUMMARY:PhD defense of Sanaa DAAKOUR - 8/12/2022 DESCRIPTION:\n \;\n\n\n\n \;\n\nfront of the jury composed of:- Ms Andréa Pasc\, Professor\, University of Lorraine\, Nancy- Rapporteur- Mr Cédric Mayer\, Professor\, Université Paris-Saclay\, Paris - Rapporteur- Mr Suming Li\, Research Director\, CNRS\, Montpellier - Examiner- Ms Hél ène Greige-Gerges\, Professor\, Lebanese University\, Lebanon - Examiner- Mr Houssam Rassy\, Professor\, American University of Beirut\, Lebanon - Examiner- Mr Mihail Barboiu\, Research Director\, CNRS\, Montpellier - Fre nch PhD supervisor- Mrs Gihane Nasr\, Professor\, Lebanese University\, Le banon - Lebanese PHD superisor\n \;\n Abstract: The original explorato ry research carried out for this report consists of a novel design of func tional and hybrid nanomaterials assembled through supramolecular interacti ons and dynamic covalent chemistry. Poly(amidoamine) (PAMAM) dendrimers in teract with liposomes through supramolecular interactions to form hybrid n anosystems. The presence of G4 PAMAM increased the encapsulation efficienc y of p-CA compared to single liposomes and slowed down its release. Theref ore\, our attempt to combine dendrimer and liposome seemed to be beneficia l to encapsulate low-water soluble molecules. PEGylated dynamic constituti onal frameworks (DCFs) were synthetized via aldehyde/amino_imine chemistry . The implementation of DCFs within liposomes or gold nanoparticles to gen erate cross-linked networks that can self-fabricate\, adapt\, and respond\ , in a controlled fashion is unprecedented. Advances in the synthesis of l iposomes\, gold nanoparticles (AuNps) and functional DCFs were reported\, differing in the concentration and composition. The nanometric and spheric al morphology of DCFs/liposomes hybrid networks support their use as carri er devices for p-CA. They increased significantly the solubility of p-CA d ue to its physical entrapment additionally to possible hydrophobic and ele ctrostatic interactions. Furthermore\, the release of p-CA was sustained d uring time. We synthesized double cross-linked Au-DCFs networks with multi ple integrated functions. Several strategies were elaborated and optimized to ensure best immobilization of carbonic anhydrase that catalyze the rev ersible hydration of carbon dioxide. High binding affinity and activation effects were demonstrated within DCFs and Au-DCFs networks. To conclude\, we developed hybrid networks as intelligent materials that are self-fitted by adaptation to the environment. These features output their performance in drug delivery and enzyme activation compared to corresponding static a nd single systems.\n \;\nKeywords: dynamic constitutional chemistry – liposomes - PAMAM dendrimers - gold nanoparticles - dynamic constituti onal networks - para-coumaric acid – carbonic anhydrase activation.\n&nb sp\; CATEGORIES:Soutenance END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Paris X-LIC-LOCATION:Europe/Paris BEGIN:STANDARD DTSTART:20221030T020000 TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET END:STANDARD END:VTIMEZONE END:VCALENDAR