Ultra-Highly Sensitive Electrical Detection of Breast Cancer Biomarkers Using Graphene Field Effect Transistors Decorated with Metal Nanoparticles
Cecília de Carvalho Castro e Silva
MackGraphe- Graphene and Nanomaterials Research Center
Mackenzie Presbyterian University.
The electrical conductivity of graphene-based transistors can be modified through interaction with chemical or biological species. Due to the high surface area and high charge carrier mobility of graphene, these devices exhibit high electrical sensitivity1. Recently, several reports have demonstrated that graphene-nanoparticles hybrid structures can act synergistically to offer a number of unique physicochemical properties. In this seminar, we will address the effect of incorporation of gold (Au) nanoparticles on the monolayer graphene (produced by chemical vapor deposition (CVD) process) and their implementation into arrays of Field Effect Transistors (FETs). The sensitivity of these devices in the label-free detection of HER-2, one of the most common proteins that act as biomarkers for breast cancer, will be explored, aiming to achieve a biosensor with sensitivity in a magnitude of a thousand times lower than the achievable level performed by routine clinical detection.
Cecília de Carvalho Castro e Silva graduated in Chemistry from Universidade Estadual de Maringá (UEM) in 2008 and her master (2011) and PhD (2015) degree in Chemistry at the Universidade Estadual de Campinas (Unicamp), Brazil. During her PhD studies, she participated of an internship program in the Department of Materials and Engineering at Rutgers University, USA 2013-2014. Since January of 2016, she is assistant professor and research member at MackGraphe – Mackenzie Presbyterian University. Cecilia has expertise in synthesis, functionalization and characterization of nanomaterials, electrochemical devices, microfabrication techniques, development of miniaturized devices based on nanomaterials as carbon nanotubes and graphene field-effect transistors (FETs) for biosensing applications. Her research interests and goals are related to the use of 2D materials in the development of flexible and portable devices for biosensing and energy conversion.